Endothelial stomatal and fenestral diaphragms in normal vessels and angiogenesis
نویسندگان
چکیده
منابع مشابه
Endothelial stomatal and fenestral diaphragms in normal vessels and angiogenesis
Vascular endothelium lines the entire cardiovascular system where performs a series of vital functions including the control of microvascular permeability, coagulation inflammation, vascular tone as well as the formation of new vessels via vasculogenesis and angiogenesis in normal and disease states. Normal endothelium consists of heterogeneous populations of cells differentiated according to t...
متن کاملPV-1 is a component of the fenestral and stomatal diaphragms in fenestrated endothelia.
PV-1 is a novel endothelial protein shown by immunocytochemical tests to be specifically associated with the stomatal diaphragms of caveolae in lung endothelium. Although the highest expression levels of both mRNA and protein are in the lung, PV-1 also has been found to be expressed in other organs. Using a specific antibody to the extracellular domain of PV-1, we have extended the survey on th...
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The route by which water, solutes, and macromolecules traverse the endothelial cell has long been a subject of study for both physiologists and cell biologists. Recent physiologic studies describe a slit-shaped pore (5.1-5.7-nm wide) as the communicating channel, although no channel of such dimensions has been visible in electron microscopic preparations. That this channel should be found withi...
متن کاملPV1 is a key structural component for the formation of the stomatal and fenestral diaphragms.
PV1 is an endothelial-specific integral membrane glycoprotein associated with the stomatal diaphragms of caveolae, transendothelial channels, and vesiculo-vacuolar organelles and the diaphragms of endothelial fenestrae. Multiple PV1 homodimers are found within each stomatal and fenestral diaphragm. We investigated the function of PV1 within these diaphragms and their regulation and found that t...
متن کاملPlasmalemma vesicle-associated protein: A crucial component of vascular homeostasis
Endothelial subcellular structures, including caveolae, fenestrae and transendothelial channels, are crucial for regulating microvascular function. Plasmalemma vesicle-associated protein (PLVAP) is an endothelial cell-specific protein that forms the stomatal and fenestral diaphragms of blood vessels and regulates basal permeability, leukocyte migration and angiogenesis. Loss of PLVAP in mice le...
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ژورنال
عنوان ژورنال: Journal of Cellular and Molecular Medicine
سال: 2007
ISSN: 1582-1838,1582-4934
DOI: 10.1111/j.1582-4934.2007.00075.x